Arctic marine ecosystems are threatened by increasing risks of chemical contamination under the combined effects of climate change and human activities. Rapid change of the cryosphere is for instance releasing large amounts of contaminants trapped in sea-ice, permafrost and terrestrial glaciers over the last decades. Sea-ice disappearance is opening new shipping areas to polluting human industries. The general warming of ocean water masses is affecting the cycle of some contaminants, thereby increasing exposure of marine organisms. In that context, providing a large-scale and comprehensive understanding of the Arctic marine food-web contamination is essential to better apprehend impacts of anthropogenic activities and climate change on the exposure of Arctic species and humans to contaminants. Among contaminants which could have high impacts on Arctic organisms, biodiversity and ecosystems, mercury (Hg) has raised major environmental concerns. Based on a large, pan-Arctic scale approach combining Hg analyses with biotelemetry, and by using the seabird community as bio-indicator of the environmental global contamination, we aim at (1) monitoring spatio-temporal variations of Hg in Arctic biota. (2) Defining Arctic hotspots of Hg contamination and highlighting sensitive areas that require particular attention and protection. (3) Identifying non-Arctic sources of Hg contamination for migratory Arctic predators.